At the age of just seven, Luise Wolfram played her first film role in ›Engelchen‹ and at 15 she appeared in ›Polizeiruf 110‹. From 2010 to 2015, she was a member of the ensemble at the Schaubühne Berlin. With this theatre company, this actress received numerous awards including the Russian theatre prize ›Die goldene Maske‹, the ›Friedrich Luft Prize‹ and the Canadian ›Prix de Critique de I’Association Québécoise des Critiques de Théatre‹. Alongside her work as a stage actress, Luise Wolfram regularly appears in films and on television.

In 2016, Luise Wolfram made her debut as Linda Selb in Bremen’s ›Tatort‹. Since 2021, she has appeared regularly in that same series as a detective alongside Jasna Fritzi Bauer. At the end of 2017, she played her first international role in the historical drama ›Mathilda‹. Other projects by this versatile actress include the two-part drama ›Aenne Burda – die Wirtschaftswunderfrau‹ and the second series of the successful show ›Charité‹. In autumn 2020, Luise Wolfram appeared in the German-Israeli cinema production ›Kiss Me Kosher‹ as well as in the mockumentary ›How to Tatort‹. This was followed in 2022 by the third season of the internationally acclaimed series ›Das Boot‹ on SKY. Alongside her work as an actress, Luise Wolfram also narrates audiobooks.